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Effect of Continuous Positive Airway Pressure on Time to Resolution of Dengue-associated Pleural Effusion

Principal Investigator : Chaisith Sivakorn, Clinical tropical medicine, Mahidol University

Project Status : On-going

Project Summary

Dengue is a mosquito-borne tropical disease that is common in more than 120 countries worldwide and affects millions of people every year. Recently, there has been a marked uptick in the reported number of Dengue cases worldwide.  Of the major complications associated with Dengue, pleural effusion is one of the most common. Approximately 75% of all Dengue patients develop pleural effusion. This can then lead to shortness of breath, pleuritic chest pain and mild to severe hypoxemia.  The most pressing issue facing treatment of dengue related pleural effusion is the lack of clear treatment guidelines. Currently the WHO has standard protocol in treatment of Dengue related pleural effusions and treatments are now dictated by severity. However early interventions have been shown to be effective in ameliorating the situation. Thus, the need for a noninvasive early intervention is necessary. Dr. Chaisith Sivakorn is working on establishing a protocol that would use Continuous Positive Airway Pressure (CPAP) machine as a noninvasive early treatment to increase the speed of recovery in patients with dengue related pleural effusion.